Browsing by Author "Frantzen, Jan Ole"

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    • Associations of breast cancer related exposures and gene expression profiles in normal breast tissue - The Norwegian Women and Cancer normal breast tissue study 

      Krum-Hansen, Sanda; Standahl-Olsen, Karina; Anderssen, Endre; Frantzen, Jan Ole; Lund, Eiliv; Paulssen, Ruth H (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01-08)
      Background Normal breast tissue is utilized in tissue-based studies of breast carcinogenesis. While gene expression in breast tumor tissue is well explored, our knowledge of transcriptomic signatures in normal breast tissue is still incomplete. The aim of this study was to investigate variability of gene expression in a large sample of normal breast tissue biopsies, according to breast cancer related ...

    • Peripheral blood cells inform on the presence of breast cancer: A population‐based case–control study 

      Dumeaux, Vanessa; Ursini‐Siegel, Josie; Flatberg, Arnar; Fjøsne, Hans Erikssønn; Frantzen, Jan Ole; Holmen, Marit Muri; Rodegerdts, Enno; Schlichting, Ellen; Lund, Eiliv (Journal article; Tidsskriftartikkel; Peer reviewed, 2014-06-14)
      Tumor–host interactions extend beyond the local microenvironment and cancer development largely depends on the ability of malignant cells to hijack and exploit the normal physiological processes of the host. Here, we established that many genes within peripheral blood cells show differential expression when an untreated breast cancer (BC) is present, and harnessed this fact to construct a 50-gene ...